Pathogenesis and prognostication in acute lymphoblastic leukemia

Pathogenesis and prognostication in acute lymphoblastic leukemia

The process of lymphoid maturation is tightly controlled by the hierarchical activation of transcription factors and selection through functional signal transduction. Acute lymphoblastic leukemia (ALL) represents a group of B/T-precursor-stage lymphoid cell malignancies arising from genetic alterations that block lymphoid differentiation and drive aberrant cell proliferation and survival. With ...

Molecular pathogenesis of childhood acute lymphoblastic leukemia.

This concise review focuses on the most recent advances in understanding molecular genetic abnormalities in childhood acute leukemia (ALL). An increasing number of chromosomal translocations associated to distinct molecular genetic abnormalities have been described. Recurrent motifs have been recognized behind the great heterogeneity of genes involved in chromosomal translocations occurring in ...

Bone Scintigraphy in Acute Lymphoblastic Leukemia

Leukemia is the most common childhood cancer and accounts for 30-40% of all malignancies. A retrospective review  was performed of the hospital records of 9 children, 6 boys and 3 girls, aged  from 2.5 to 15 years with ALL initially referred to Nemazee hospital Nuclear medicine center for whole body bone scanning between 2000 and 2002. Bone marrow pathology established ALL (L1) in two and ALL (...

Simultaneous Neuroblastoma and Acute Lymphoblastic Leukemia in an Infant

Leukemia Cutis in a Child with Acute Lymphoblastic Leukemia at Diagnosis and Relapse

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